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Many anti-angiogenic therapies, such as VEGF inhibitors, suppress tumor growth and metastasis by blocking angiogenesis and repairing abnormal endothelial cells [199, 200]

The results showed both the higher and lower Mw compounds resulted in substantial lesions and an increase in myeloperoxidase, and infiltration of neutrophils (Benard et al

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Common adverse effects include: Gastrointestinal symptoms Nausea, vomiting, diarrhoea, and constipation are the most frequently reported side effects, particularly during treatment initiation