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doi: 10.3389/fphar.2025.1602976 Received 30 March 2025 Revised 13 November 2025 Accepted 14 November 2025 Published 19 December 2025 Volume 16 - 2025 Edited by Bernd Rosenkranz, Fundisa African Academy of Medicines Development, South Africa Reviewed by Kacper Nijakowski, Poznan University of Medical Sciences, Poland Miriam Njoki Karinja, Science for Africa Foundation, Kenya Updates Copyright 2025 Mazur, Ndokaj, Salerno, Vallone, Ardan, Bietolini, Carrouel, Wilk, Sarig, Ottolenghi and Bourgeois
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Engineered exosomes called (Exo-pYSTAT3 IB) were produced using EXPLOR, these small exosomes were loaded with an mCherry-tagged intracellular antibody (intrabody, IB) targeting a Tyr705-phosphorylated signal transducer and activator of transcription 3 (pYSTAT3)
By replenishing the intracellular pools of this master antioxidant, the body can begin to shield its vulnerable mitochondria from ongoing free radical damage
Sezen, and M
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