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In SURPASS-2, tirzepatide caused diarrhea in 13-16% of participants, while semaglutide 1 mg caused it in 12%

But just to state the obvious, these drugs have been in global sort of heavy use for, let's say, 10 to 15 years thus far, which is not very long, especially given the fact that people are using it off-label

Because semaglutide directly affects gut movement and the release of digestive enzymes, it can easily disrupt the natural rhythm of digestionespecially during the first few weeks of treatment

Over-the-Counter Supplements FDA Approval : Semaglutide is FDA-approved for weight loss

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