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Challenges include inefficient homing and the potential for fibrotic transformation under chronic inflammation, necessitating the engineering of MSCs with enhanced renal tropism

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Jastreboff, MD, PhD Director, Weight Management & Obesity Prevention Yale School of Medicine, New Haven, Connecticut Professor Ania Jastreboff has been a principal investigator for pivotal GLP3 clinical trials, including the landmark phase 2 obesity study published in the New England Journal of Medicine

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124 Another example is the ER-resident E3 ubiquitin ligase RNF13, which interacts with IRE1 to enable TRAF2 signaling