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Glucocorticoids, inflammation and bone

After a 36-week induction with maximal doses (10 or 15 mg), participants averaged about 20.9 percent body weight loss, then those switched to placebo regained roughly 14 percent of that week 36 body weight over the following 52 weeks, while continuers lost another 5.5 percent, leaving a final average loss of 25.3 percent for continuers versus 9.9 percent for the switch group

Current management for MASLD primarily relies on lifestyle modifications, with limited pharmacological options

Moreover, deficiencies or dysfunctions in transcobalamin II, which is essential for transporting B12 in the bloodstream, can further impact its bioavailability