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How This Compares to Tirzepatide and Semaglutide The honest version of the comparison: cross-trial comparisons in obesity are unreliable

(3) Dietary factors

"Certainly, oral dosing is preferable to injections for an awful lot of people." During an earnings conference call with investors in February, Novo executives stressed the importance of a fast launch for the company's oral medications

For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]

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