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Bilirubin causes protein oxidation, lipid peroxidation, decreased cellular glutathione content, increased lactate dehydrogenase levels, and nitric oxide release (via neuronal nitric oxide synthase activation via N-methyl-d aspartate receptor activation)
Cell 117: 601610 Gross E, Sevier CS, Heldman N, Vitu E, Bentzur M, Kaiser CA, Thorpe C, Fass D (2006) Generating disulfides enzymatically: reaction products and electron acceptors of the endoplasmic reticulum thiol oxidase Ero1p
As the cell proliferation activity of normal skin was greatly reduced after UVA irradiation, the effect of Tripeptide copper-1 is tested by the content change of collagen type I after UVA irradiation
V.HabashiN.McCunnM.ShihD.McQuillanK.et al (2007)