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Non-Billable Substances and the Entire-Claim Denial Risk for CPT 64483 Substances That Cause Denial of the Entire CPT 64483 Claim Per CMS Billing and Coding Article A56681, inclusion of a biological or non-FDA-approved substance in the 64483 injectant may result in denial of the entire claim, not just the individual 64483 line

In addition, berberine can properly restore the levels of 3-nitrotyrosine (3-NT), COX 2, glial fibrillary acidic protein (GFAP), and sirtuin 1 in the hippocampus (Sadraie et al., 2019)