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Although there is literature based on investigating the cross-sectional association between UPFs and mental disorders, there continues to be a relative lack of high-quality evidence on the prospective effects of UPFs as a risk factor for the development of mental disorders, as well as the pathophysiological mechanisms involved (21, 22)

Knockout of TBC1D9B or its binding partner TMEM55B causes lysosome dispersion, defective autophagic flux, and impairs the adaptive degradative response of cells to limiting nutrient supply

However, oral mucosal irritation may occasionally occur with the ODT formulation, manifesting as mild burning, tingling, or temporary alteration in taste sensation

Yet, casecontrol studies in adults show a potential increased risk of psychiatric outcomes