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Zinc has been shown to modulate several crucial immune pathways, enhancing chemotaxis in neutrophils [12], promoting cytotoxic activity in NK cells [13], supporting macrophage phagocytic function [14], and preserving responsiveness of T and B cells [15, 16], which are essential components of adaptive immunity

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Notably, these alterations occur prior to the onset of inflammation and induce the upregulation of epithelial-derived cytokines such as thymic stromal lymphopoietin (TSLP) and interleukin-33 (IL-33), which subsequently activate the Th2 immune axis in a sustained manner (Jo et al., 2018

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