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These effects typically peak during dose titration and improve over time but cause 20-50 percent of patients to discontinue treatment within the first year

When to call a healthcare provider Severe or persistent abdominal pain, abdominal pain that radiates to the back, persistent vomiting, signs of dehydration, fainting, severe weakness, symptoms of an allergic reaction, or symptoms suggestive of gallbladder disease such as right-upper-quadrant pain or fever warrant prompt clinical evaluation