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21 reasoned that L-CYSee or its free radical cation 46 reversed the effects of morphine via its reductive capacity, which down-regulates ORs 47 or affects OR function by effects on membrane-associated proteins 48

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Interestingly, in patients suffering from neuropathic pain the pain intensity tends to maximise in the evening ( However, there are still considerable limitations of existing data on the chronopharmacological component of nerve regeneration therapy and further indepth studies need to be carried out