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Clinical validation across the comprehensive SURPASS and SURMOUNT trial programs has established tirzepatide as producing the most substantial weight loss and glycemic improvements of any pharmacological agent to date [3] [4]

Die Studie wurde nach einer mittleren Behandlungsdauer von knapp 40 Monaten abgeschlossen, nachdem eine vordefinierte Anzahl (1225) von primren Endpunkt-Ereignissen eingetreten war

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Non-receptor-mediated actions are due to amphipathic properties (of both lipo- and hydrophilic structure) that allows melatonin to freely cross the cell and nuclear membranes