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The following dosing protocol is provided as a reference for the investigation of cagrilintide's efficacy in weight management among obese participants in ongoing phase 3 trials: Cagrilintide Weekly Dose : Researchers start with a dose of 0.25mg/weekly for the initial four weeks, then escalate to 0.5mg/weekly for weeks 5-8, progress to 1mg/weekly for weeks 9-12, increase to 1.7mg/weekly for weeks 13-16, and finally reach a maintenance dose of 2.4mg/weekly from week 17 onwards

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The behavioral consequence of this circuit is well-documented: optogenetic stimulation of VTA GABA neurons directly suppresses the activity and excitability of neighboring DA neurons [48] and, critically, this suppression disrupts reward consumption while leaving anticipatory behavior intact [49]