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The storage lesion is exacerbated in some categories of donors as a function of biology (sex, age) 21 , genetic traits 22,23,24,25 , and lifestyle-associated exposures 26 (comprehensively reviewed in 15,21,27,28

When your body has less toxins, it functions better and youll notice more energy

Knauf C, Cani PD, Perrin C, et al

However, discontinuation without maintaining lifestyle changes may lead to weight regain

The DAPA-HF, EMPEROR-REDUCED, EMPEROR-Preserved, DELIVER and other trials mentioned above consistently demonstrate the efficacy of SGLT-2i in patients with HF, regardless of LVEF or the presence of diabetes