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Modulation of glucagon-like peptide-1 (GLP-1) potency by endocannabinoid-like lipids represents a novel mode of regulating GLP-1 receptor signaling

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Exenatide LAR exhibited durable glucose-lowering efficacy, with stable glucose improvements and reductions in cardiometabolic risk factors for up to 3 years, and a tolerable safety profile [70]

There is also a small risk of kidney injury if severe vomiting, diarrhea, or dehydration occur