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In a three-month study with 58 hypertensive patients, taking the anti-hypertensive drug nifedipine (a calcium channel blocker), the plasma levels of vasoconstrictor molecule endothelin-1 were significantly lowered by 9% after one month and by 16% after three months in the group taking 100 mg Pycnogenol compared to the placebo group ( compared to the placebo group

Conversely, inhibition of the PI3K/AKT/mTOR signaling axis sensitizes cancer cells to ferroptosis induction (111)

Interestingly, some drugs based on the study of the regulatory mechanisms of ferroptosis in ovarian diseases, such as cryptotanshinone, N-acetylcysteine, rutin etc., has significantly improved ovarian function