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On the one hand, TME immunomodulation can trigger macrophage polarization from alternately activated macrophages M2 to classically activated macrophages M1, offering intertumoral H 2 O 2 for the Fenton reaction (Zanganeh et al., 2016), which effectively generates ROS and triggers lipid peroxidation (Yang and Stockwell, 2016

It might be that the lower SOD activity of positive animals reflects excessive consumption of the enzyme (antioxidant consumption hypothesis) to buffer increased superoxide production rather than an inhibitory effect (antioxidant inhibition hypothesis) of viral infection on the enzyme 35

In particular, mercury is much more toxic with respect to other thiol-binding metals: as an indication, the DL 50 values of some water-soluble salts are: HgCl 2 (oral, rat): 3.7 micromoles/kg

Both studied angiogenesis and wound healing models