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Continually reevaluate patients receiving hydrocodone bitartrate and acetaminophen tablets to assess the maintenance of pain control, signs and symptoms of opioid withdrawal, and other adverse reactions, as well as reassessing for the development of addiction, abuse, or misuse (see WARNINGS)

The effects of lactose, sucrose, and mannitol on the freeze-drying process, as well as the effect of lactose carrier amount on aerodynamic performance of DPI were evaluated

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