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Rufinamide: Clinical pharmacokinetics and concentrationresponse relationships in patients with epilepsy

Skin penetration limits how much peptide absorbs regardless of concentration

Clinicians should monitor thyroid function tests (TSH, free T4) at: Baseline before starting weight loss injections 6-8 weeks after achieving maintenance dose Every 3-6 months during active weight loss After significant weight stabilization Symptoms of overreplacement (palpitations, anxiety, tremor, heat intolerance) should prompt earlier testing

Thyroid ultrasound

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