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They found that NNMT knockdown reduced the insulin level and improved glucose tolerance in female mice fed with a Western diet and that NNMT knockout strongly improved insulin sensitivity in male mice fed with a high-fat diet [28]
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Experiments studying the effects of acute cold-exposure in HFD-fed obese VasTg mice may enable the acute anti-thermogenic/anti-lipolytic effects of vaspin to be separated from the long-term anti-inflammatory effects in brown and white adipocytes
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