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The defining feature of the DAC version, per Jett et al

Some irAEs, such as thyroid disease, are treatable and the damage reversible

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Stability: Glutathione is notoriously unstable

The cellular metabolic competition in the tumor microenvironment, such as the intense competition between cancer cells and immune cells (especially activated T cells and macrophages with specific functions) for the limited glutamine, forces adaptive evolution in the cell population and drives the formation of glutamine metabolic heterogeneity