The rationale and design across its trials were described by Giblin and colleagues in Diabetes, Obesity and Metabolism in 2026 (PMID 41090431)
While it rarely causes dangerously low blood sugar on its own in people without type 2 diabetes, taking a massive overdoseespecially if combined with other medications like insulin or sulfonylureascould potentially lead to hypoglycemia
This task requires a concerted action of many players: specific genes expression, post-transcriptional and post-translational regulation, hormones, and cell regulators
This dual effect helps to regulate blood glucose levels with a low intrinsic risk of hypoglycaemia, as the insulin response diminishes when blood sugar normalises
Lopez-Delgado MI, Morales M, Villanueva-Penacarrillo ML, Malaisse WJ, Valverde I