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The rationale and design across its trials were described by Giblin and colleagues in Diabetes, Obesity and Metabolism in 2026 (PMID 41090431)

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While it rarely causes dangerously low blood sugar on its own in people without type 2 diabetes, taking a massive overdoseespecially if combined with other medications like insulin or sulfonylureascould potentially lead to hypoglycemia

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This task requires a concerted action of many players: specific genes expression, post-transcriptional and post-translational regulation, hormones, and cell regulators

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This dual effect helps to regulate blood glucose levels with a low intrinsic risk of hypoglycaemia, as the insulin response diminishes when blood sugar normalises

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Lopez-Delgado MI, Morales M, Villanueva-Penacarrillo ML, Malaisse WJ, Valverde I

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