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A meta-analysis of five trials in participants with either impaired fasting glucose, type 2 diabetes mellitus, or nonalcoholic steatohepatitis found evidence of an improvement in insulin resistance with supplemental L-carnitine compared to placebo (43)

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The loss of lean body mass, or muscle, occurs as a normal result of substantial weight loss in people who have excess body fat and who live sedentary lives, Quebbemann says

Regarding hormone-related supplements, these should generally be avoided until after puberty and preferably into the late teens or early twenties