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EC 1.11.1.6) activity was determined after Aebi [23]

Subsequently, the insulin signaling pathway was investigated in the liver by examining phosphorylation of insulin receptor substrate 1 (pIRS1)-Ser307 and phosphorylation of protein kinase B (pAKT)-Ser473

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This could lead to subtherapeutic thyroid hormone levels, manifesting as fatigue, weight gain (counteracting Wegovy's intended effect), cold intolerance, or other hypothyroid symptoms