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Devirian TA, Volpe SL

Recent years have seen a paradigm shift in MASLD research, moving beyond static metabolic abnormalities toward a more integrated view that includes endocrine, immunological, and chronobiological inputs

These recommendations consider the main clinical targets in PCOS (insulin resistance, lipid imbalance, hormonal dysfunction), the most effective dosages and durations, and the current level of supporting evidence

Therapeutic treatment was multi-layered: nutrition, nutraceuticals, acupuncture, anti-stress and meditative techniques, support for physical activity and psychotherapy

Its strength lies in coordinated biochemical signaling that supports the bodys innate repair intelligence rather than replacing standard medical care