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Moreover, the redox-sensitive Keap1-Nrf2 pathway is activated in nucleated cells following oxidative stress to provide an adaptive and protective response by antioxidant enzymes upregulation [215], which is not possible in mature erythrocytes

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The cytotoxicity of As 2 O 3 occurred through the generation of reactive oxygen species (ROS), thus inhibiting radical scavenging systems would enhance the therapeutic efficacy of As 2 O 3 provided that normal cells were relatively resistant to such a measure

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