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Gingrich J, Choudhuri S, Cournoyer P, Downey J, Muldon Jacobs K
445 participants: 12 mg: average 28.7% body weight loss WOMAC knee pain scores dropped by up to 75.8% More than 1 in 8 patients became completely pain-free Systolic blood pressure improved by 14.0 mmHg TRANSCEND-T2D-1 Type 2 diabetes (40 weeks) Published March 2026
Cell Reports 23(11):3392-3406, 2018
Monitor Response and Safety Follow appetite, side effects, weight, blood pressure, adherence and medication tolerance
Plan for 5-15 pounds as your body adjusts to lack of pharmacological support Hunger will be significantly higher off medication
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