For example, (1) Glucagon-like peptide 1 (GLP1) is an intestinal hormone that can enhance insulin secretion in a glucose-dependent manner by activating the GLP-1 receptor (GLP-1R) that is highly expressed on islet cells
FDA Clears First Oral GLP-1 for Weight Loss On December 22, 2025, the FDA approved Novo Nordisks once-daily Wegovy pill (25 mg semaglutide), the first oral GLP-1 receptor agonist indicated for chronic weight management and cardiovascular risk reduction in adults with obesity or overweight plus at least one weight-related comorbidity
It also provides access to educational content, virtual group sessions with Mayo Clinic doctors, a digital platform with a food tracker and other tools to help reinforce health-promoting habits, and practical at-home, equipment-free workouts
What they found stopped people in their tracks: 4,048 human genes affected by a single tripeptide
High-intensity interval training (HIIT): Can be effective for improving cardiovascular health and burning fat