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Selon lun des auteurs de cette lettre, Shubham Agarwal, lengouement pour les agonistes du GLP-1 ouvre la porte de nombreuses questions, dont : Une perte de poids rapide est-elle meilleure quune perte de poids plus lente

Some drugs have been proposed to accelerate -cell loss (e.g., glibenclamide and glyburide) [23], while other drugs such as peroxisome proliferator-activated receptor-gamma (PPAR) agonists, GLP-1 receptor agonists, dipeptidyl peptidase-4 (DPP-4) inhibitors, glycogen synthase kinase 3 (GSK3) inhibitors, or G protein-coupled receptor 40 (GPR40) agonists have been suggested to protect -cell function [16]

They found that the NRF2 activators attenuated markers of kidney damage and minimized glomerular pathology in wild-type but not in Nrf2 knockout mice [50]

The human body has evolved sophisticated systems to maintain energy balance

The most significant factor is likely related to rapid weight loss and associated nutritional changes