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While the top of TM6 and ECL3 could not be confidently modelled for the exendin-4 complex, the portion of TM6 and TM7 that were modelled, along with the weak density corresponding to ECL3 supports a backbone conformation more similar to GLP-1 and oxyntomodulin bound receptors, rather than exendin-P5, albeit it is likely that this region is more conformationally dynamic

doi:10.1111/j.1600-079X.2007.00499.x McGlashan EM, Nandam LS, Vidafar P,Mansfield DR, Rajaratnam SMW, Cain SW