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Psychiatry 61 , 705713 (2004)

doi: 10.1056/NEJMoa1811744 12 MarsoSPDanielsGHBrown-FrandsenKKristensenPMannJFNauckMAet al

Patient Readiness and Expectations The successful introduction of GLP-1 depends on patient understanding, psychological readiness, and long-term commitment: Mechanism Awareness: Patients must understand that GLP-1 facilitates a caloric deficit and is not a substitute for dietary and lifestyle management

Selective Senescent Cell Clearance: The peptide exhibits potent senolytic activity by targeting the FOXO4-p53 axis, a key regulator of cell aging and the aging process

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