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Active cancer or suspected cancer requires careful consideration

However, the FDA has cited possible negative side effects that may result from using glutathione, especially when combined with injectable vitamin C, such as possibly getting skin cancer, the formation of kidney stones if the persons urine is acidic, and hemodialysis for those with glucose-6-phosphate dehydrogenase (G6PD) deficiency

However, if polymorphisms in the glucoronosyI transferases reduce the V max values to 50% of normal then the number of hepatocytes drops to about 75% of normal after 20 hours

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Reiter R: Oxidative damage in the central nervous system: protection by melatonin