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Despite the above-mentioned disease burden, there is currently no available FDA- or EMA-approved medication for the disease, although numerous agents have been investigated in preclinical and clinical studies [5]

Intestinal microbiota during infancy and its implications for obesity

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In addition, brain-region specificity may influence antioxidant readouts, such as cortex, hippocampus, striatum, and cerebellum show distinct redox and metabolic profiles in ASD models

Oridonin, a diterpenoid compound isolated from Rabdosia rubescens , was shown to alleviate PI-IBS symptoms in rats by significantly inhibiting phosphorylation of NF-B p65 and downregulating downstream inflammatory mediators such as inducible nitric oxide synthase (iNOS), COX-2, IL-1, and IL-6