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This study is one of many to link ferroptosis to neurodegeneration, as targeting the pathway has become a promising therapeutic strategy for age-related diseases, alongside another growing area of interest: senescence

Clearly, many of the reported effects of DEM on 3T3 fibroblasts last for no more than 3 days and at day 6 DEM treated cells show a profile of glutathionylated proteins similar to controls, although nuclear carbonyls remain higher in cells incubated with DEM

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Biochem J 307 : 543548 Axelrod L et al

Researchers tracking how this evidence base matures can compare it with the companion assessment of whether current research supports cagrilintides role in lowering stroke risk, which weighs a similarly early evidence base for a different endpoint