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Therefore, targeting the System Xc /GSH/GPX4 axis while minimizing side effects represents a major ongoing challenge and a key direction for future PDAC therapy

These correlations have been cited in support of the concept of the leaky gut wherein inflammatory states increase paracellular permeability to endotoxins and bacteria

Deoxyhypusine hydroxylase is encoded by the DOHH (deoxyhypusine hydroxylase/monooxygenase) gene