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Vitamin B12 plays a vital role in producing serotonin, a hormone that regulates mood and can help to alleviate symptoms of depression

[6] Two Types of TMAU Primary TMAU is geneticcaused by loss-of-function mutations in the FMO3 gene

The deficiency is not lethal for humans but prevents severe attack of malaria since the oxidative stress released in the erythrocytes renders the milieu hostile for Plasmodium which cannot pursue its growth cycle efficiently

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This effect is modest in healthy individuals with adequate protein intake but becomes meaningful when protein is already insufficient