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Degraded ECM means compromised communication, leading to disorganized repair attempts that produce visible texture irregularities rather than smooth, youthful skin

It is this dynamic that has made measurement of serum ceruloplasmin the primary screening test for Wilsons.16 Ultimately, the excess retained copper in the hepatocytes of Wilsons patients leads to toxic injury to the cell and eventually spillage of copper into the circulation, where it may be deposited in other organs such as the brain, cornea, and kidneys

PHGDH , PSAT1 , PSPH and SHMT2 , compared to the adjacent normal lung tissue, which hardly showed any expression of ser/gly pathway enzymes

Indeed, Hu et al

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