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In the REDEFINE 1 phase 3 trial (NCT05567796), which enrolled adults with overweight or obesity (BMI 27 kg/m) and at least 1 weight-related comorbidity but without type 2 diabetes, participants receiving CagriSema (cagrilintide 2.4 mg + semaglutide 2.4 mg) achieved a mean body weight reduction of 22.7% from baseline after 68 weeks among adherent participants, compared with approximately 3% in the placebo group.5 These results establish CagriSema as one of the most potent antiobesity therapies investigated to date

Cardiovascular Diabetology, 35(4), 178-185

Most recently, we have shown that systemic administration of GLP-1 (9-36) enhances hippocampal long-term synaptic plasticity (Day, 2017), as shown in the left figure

DHT blockers such as finasteride and dutasteride can promote hair growth

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