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As a key trial evaluating the efficacy of tirzepatide, SURMOUNT-1 (NCT04184622) was consistent with the SURPASS studies in demonstrating dose-dependent weight loss [66]

Nausea Vomiting Constipation Diarrhea Acid reflux Bloating Reduced appetite Stomach discomfort Most side effects improve gradually after the body adapts to treatment

Main effects were evident for L-carnitine supplementation across treatments for plasmatic uric acid (UAc), cholesterol (TC) and low density lipoprotein (LDL),(Table 5)