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Moreover, betaine prevented the liver from ethanol-induced steatosis in rats by increasing the hepatic SAM levels ( Hyperhomocysteinemia is known to induce ER stress, which can activate sterol regulatory element-binding proteins (SREBPs) and upregulate enzymes in lipid synthesis, contributing to triglycerides and cholesterol accumulation and also induces apoptosis (Kaplowitz and Ji, 2006

These data suggested that berberine ameliorates diabetic conditions in db/db mice

It also washes off, which is a nice feature when you change your mind

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