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The bulk of data sits in rodent models, with the brain-gut axis as the theoretical framework that connects the peripheral and central effects
Expanding on these data, additional modifications intended to increase hydrophobicity and decrease hydrogen bonding potential yielded N- hexanoic-Tyr-Ile-(6)-aminohexanoic amide (dihexa), a potent cognitive enhancing molecule that proved to be very stable, to be capable of inducing spinogenesis/synaptogenesis at picomolar concentrations, is slowly cleared from the blood compartment, and is sufficiently BBB permeable
Optimal dosage follows a narrow window : Men need 55-75 g dailyboth deficiency and excess (over 400 g) can harm reproductive health due to selenium's U-shaped response curve
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