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NRF2 promotes the expression of NADPH-generating enzymes, including the rate-limiting enzyme glucose-6-phosphate dehydrogenase (G6PD) in the pentose phosphate pathway (PPP)
It promotes neuroplasticity in brain regions like the hippocampus by increasing BDNF levels, glutamate release, and upregulating mGLU2 receptors, particularly in the hippocampus and prefrontal cortex
People take wellbutrin because they have depression, anxiety, seasonal affective disorder, or some combination of mental health conditions that require pharmacological support
A hearing evaluation, properly fitted hearing aids, cataract care, vision correction, and fall-risk reduction may have more practical cognitive relevance for some patients than chasing the newest supplement or protocol
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