doi: 10.1111/acel.13783 70 ShihWCJangIHKruglovVDickeyDCholenskySBernlohrDA71et al
Mechanism of Action Inhibits HMG-CoA reductase, the key enzyme in cholesterol synthesis in the liver LDL cholesterol (bad cholesterol) HDL cholesterol (good cholesterol) Triglycerides Stabilizes atherosclerotic plaques and reduces vascular inflammation Uses Hypercholesterolemia (high cholesterol) Mixed dyslipidemia (abnormal cholesterol & triglycerides) Prevention of cardiovascular events (heart attack, stroke, angina) in high-risk patients Can be used in both primary prevention (before disease occurs) and secondary prevention (after an event) Common Side Effects Headache Muscle pain, weakness (myalgia) Abdominal pain, nausea, diarrhea Elevated liver enzymes Serious but Rare Side Effects Rhabdomyolysis (severe muscle breakdown kidney injury) Severe liver injury Hypersensitivity reactions Contraindications Active liver disease Pregnancy & breastfeeding (statins are teratogenic) Allergy to atorvastatin or other statins Monitoring Liver function tests (LFTs) before and during therapy Creatine kinase (CK) if muscle symptoms occur Usual Dose 1080 mg once daily, with or without food Adjust based on LDL response and patient risk profile To view or add a comment, sign in Ibuprofen is a widely used nonsteroidal anti-inflammatory drug (NSAID)
Assess the patients level of consciousness and cognitive function
(Accessed on 05 June 2024) Reuter SE, Evans AM (2012) Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects
In an ad-libitum meal experiment with varying fat content, patients with MC-4R mutations consumed 95% more of the high-fat meal compared to lean controls, and 65% more compared to obese controls
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