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The primary concern relates not to direct drug interactions between most injectable GLP-1 agonists and levothyroxine, but rather to the potential impact on thyroid monitoring and the theoretical risk associated with thyroid C-cell tumours observed in animal studies

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Mechanisms of action of glucagon-like peptide 1 in the pancreas [J]

Most say they notice a significant change after one month of therapy, with optimal results apparent after three to six months