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The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

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Its pharmacological actions on glucose metabolism involve the LKB1-AMPK pathway, which appears to activate ataxia-telangiectasia mutants and activation-induced cytidine deaminase (ATM) [20]

GLP-1 medications improve insulin sensitivity and reduce hyperinsulinemia, shifting the hormonal environment away from growth-factorrich conditions that may favor lesion survival