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Creatine can cause a small increase in body weight due to water retention inside muscle tissue

A portion of 120 to 150 grams once weekly is enough to feel its benefits

Addressing these determinants requires targeted interventions

Waist circumference improvements were also greater with the higher dose, with an average additional reduction of nearly 12 cm or 4.72 inches compared to placebo

From an engineering standpoint, microbiome-responsive hydrogels, enzyme-cleavable coatings, and dual-acting nanosystems (e.g., combining photothermal therapy with antibiotic release) require significant refinement for clinical deployment