Semaglutide has been on the market longer and has more post-marketing safety data
Over-the-counter products exist in a different regulatory category with minimal oversight, making direct comparison impossible from a scientific standpoint
Demonstrated clinical benefits of GLP-1s include improved cardiometabolic risks, fewer major adverse cardiovascular events [22], decreased mortality in heart failure [[23], [24], [25], [26], [27]], and improvements in obstructive sleep apnea [11,28], prediabetes [29,30], chronic kidney disease [31], knee osteoarthritis [32], substance use disorders [33], and metabolic-associated steatotic liver disease [34]
National Institutes of Health: National Institute of Diabetes and Digestive and Kidney Diseases: The Urinary Tract and How it Works
Non-medicinal Ingredients*: microcrystalline cellulose and sodium stearyl fumarate