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Research has demonstrated that excessive alcohol consumption is associated with increased levels of pro-inflammatory cytokines and activation of microglia, the brains resident immune cells (Mikhalitskaya et al

(2019) reveals that TDP-43 phase separation is not just a biophysical occurrence, but a central pathological mechanism in ALS and FTD, addressing the view of aggregation as a passive consequence to a dynamic and stress-induced process with functional consequences on nuclear transport and cellular survival