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The addition of glucagon receptor agonism raises theoretical considerations around heart rate elevation , and Phase 2 data did show modest increases in resting heart rate in some participants a finding that will require careful monitoring in Phase 3 cardiovascular outcome trials

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Early evidence suggests GLP-1s may reduce chronic inflammation and improve cellular function, supporting heart, liver, kidney, and brain health, and potentially lowering risk for obesity-related cancers

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instead, their diets supplement them